Before modifying default configuration settings, thoroughly understand and test their implications. Django's default configurations often include important safeguards that prevent subtle bugs. For example, the `ENQUEUE_ON_COMMIT` setting in task backends defaults to `True` for good reason: ```python @task def my_task(): Thing.objects.get(id=thing_id) # Could fail if transaction hasn't committed yet with transaction.atomic(): thing = Thing.objects.create() my_task.enqueue(thing_id=thing.id) # With ENQUEUE_ON_COMMIT=False, task might run before transaction commits ``` Similarly, the `QUEUES` restriction in task backends prevents typos that could cause tasks to be enqueued but never executed. When working with time-sensitive data, be particularly careful with timezone configurations as they can lead to unexpected query results when using functions like `Trunc` across different environments. Always test configuration changes across all target environments before deployment, as some issues only manifest in specific contexts or at scale.