When configuring CMake builds, carefully select compiler and linker flags that optimize for performance while maintaining cross-platform compatibility. Performance-oriented flags can significantly impact runtime speed, binary size, and resource utilization, but must be applied conditionally based on the target platform and compiler. Key practices: - Research the performance implications of compilation flags before applying them (e.g., `DYNAMIC_EXECUTION=0` may slow down WebAssembly bindings) - Use conditional compilation to apply platform-specific optimizations (e.g., `--gc-sections` for GCC/Clang vs `--dead_strip` for AppleClang) - Enable standard performance flags like `CMAKE_POSITION_INDEPENDENT_CODE ON` for better code generation - Consider alternative optimization strategies when default flags cause performance regressions Example of conditional linker optimization: ```cmake target_link_options(yoga PRIVATE # Discard unused sections $<$:$<$:-Wl,--gc-sections>> $<$:$<$:-Wl,-dead_strip>>) ``` This approach ensures optimal performance across different build environments while avoiding platform-specific build failures.